Red cell antibodies

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Direct identification of unexpected serum antibodies against red cell antigens.

A new method to detect the identity of unexpected antibodies in the sera of prospective transfusion recipients is presented. The method is based on a macroscopic hemagglutination inhibition assay. In this assay, incubation of phenotypically defined test red blood cells with patient sera containing non-agglutinating antibodies to one or more specific antigen systems block monoclonal IgM inductio...

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Prevalence and Haemolytic Significance of Red Cell Antibodies among Dangerous Universal Donors in a Tertiary Care Hospital in South India

Background and Aims: A subgroup of group O individuals called ‘dangerous universal donors’ have immune (IgG) anti A and anti B antibodies which are active at 37˚C and capable of reacting with the red cells and causing lysis. The aim of this study was to find the prevalence of dangerous O group among the voluntary donor population and to assess the relation between the degree of haemolysis and t...

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Anti-red blood cell antibodies, free light chains, and antiphospholipid antibodies in intravenous immunoglobulin preparations.

BACKGROUND Anti-red blood cell antibodies, free light chains (FLC) and prothrombotic proteins (PTP) may co-elute with intact immunoglobulin (IgG), and may be the cause of adverse reactions to intravenous immunoglobulin preparations (IVIG). OBJECTIVES To investigate the presence of residual amounts of these components in IVIG and their effects on ABO blood group agglutination. METHODS Iso-ag...

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Association of white cell and red cell antibodies in human sera.

Five hundred and eighteen human sera containing known red cell antibodies were tested for lymphocytotoxic antibodies and 81 sera were found to contain them. Thirty-nine antibodies were fully characterized. The frequencies of anti-I, K, V(w), and Wr(a) were significantly greater in those of the 518 sera which also contained white cell antibodies.Four hundred and ninety-four of the 518 sera conta...

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The effects of concentrated eluted anti-red blood cell antibodies on the in vivo survival of normal red blood cells.

By NEu. W. GULP AN!) HUGH CHAPLIN, Jn. P REVIOUS STUDIES of in vivo survival of sensitized red blood cells have utilized either cells from patients with immune hemolytic anemia or cells coated in vitro by antibody present in whole serum. The present study reports in vivo survival studies using normal red cells sensitized by relatively “pure” antibodies, obtained by elution from well washed, sen...

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ژورنال

عنوان ژورنال: BMJ

سال: 1987

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.295.6595.441-a